Autologous skin micro-grafts and allogenic skin allograft for mitten hand deformity treatment in epidermolysis bullosa

<p><strong>Background:</strong> In the genetic skin blistering disorder dystrophic epidermolysis bullosa recurrent blisters and erosions on mechanically stressed areas, as hands, result in subsequent scarring development of pseudosyndactylies contractures. its most severe form, all fingers are constrained into a fist scarred (“mitten-hand”-deformity). No causative therapy exists only surgical release is possible. Hereby, large defects inevitable; lack healthy autologous for grafting remains difficult challenge.</p><p><strong>Methods:</strong> We propose new technique: It adopts treatment strategy from extent burns consists combination autogenic allogenic grafting.</p><p><strong>Results:</strong> present beneficial outcome 18 mitten hand deformities treated with this technique. patients, initial functional was improved. Nearly patients got considerably widened grip span durable conditions post-operatively. Mean follow-up 3 years. Typically, recurrence occurred 6 months to 2 years after operation.</p><p><strong>Conclusions:</strong> This first report use autogenous pinch grafts (parental) overlay EB. provides undisturbed wound healing under “biological dressing”, furthermore, temporary take parental visible. Defects were permanently covered increased mechanical stability, function improved remarkably. However, long term showed beginning comparable rates described literature.</p>